(-)-(S)-B-973B

(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity.

Product information

CAS Number: 2244989-34-0

Molecular Weight: 452.50

Formula: C24H26F2N6O

Chemical Name: 3-(3,4-difluorophenyl)-N-[(1S)-1-{6-[4-(pyridin-2-yl)piperazin-1-yl]pyrazin-2-yl}ethyl]propanamide

Smiles: C[C@H](NC(=O)CCC1C=C(F)C(F)=CC=1)C1C=NC=C(N=1)N1CCN(CC1)C1C=CC=CN=1

InChiKey: WQYZERNSONBUCW-KRWDZBQOSA-N

InChi: InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 67.5 mg/mL (149.17 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148.

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