Description
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium.
Product information
CAS Number: 7562-61-0
Molecular Weight: 344.32
Formula: C18H16O7
Chemical Name: (2R)-4, 10-diacetyl-11, 13-dihydroxy-2, 12-dimethyl-8-oxatricyclo[7.4.0.0, ]trideca-1(13), 6, 9, 11-tetraene-3, 5-dione
Smiles: CC(=O)C1=C2OC3=CC(=O)C(C(=O)[C@]3(C)C2=C(O)C(C)=C1O)C(C)=O
InChiKey: CUCUKLJLRRAKFN-MCEAHNFKSA-N
InChi: InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,11,22-23H,1-4H3/t11?,18-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 6.32 mg/mL (18.36 mM; Need ultrasonic). H2O : < 0.1 mg/mL (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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