ω-Agatoxin TK

ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels.

Product information

CAS Number: 158484-42-5

Molecular Weight: 5273.02

Formula: C215H337N65O70S10

Chemical Name: 4-amino-4-({1-[(1-{[42,63-bis(4-aminobutyl)-16,81-bis(butan-2-yl)-34-[(1-{2-[(4-carbamimidamido-1-{[1-({1-[(1-{[3-carboxy-1-({[(1-{[1-({1-[(1-carboxyethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)propyl]carbamoyl}-3-(methylsulfanyl)propyl)carbamoyl]-2-methylbutyl}carbamoyl)-3-methylbutyl]carbamoyl}butyl)carbamoyl]pyrrolidin-1-yl}-3-hydroxy-1-oxobutan-2-yl)carbamoyl]-4,92,98-tris(3-carbamimidamidopropyl)-25-(carbamoylmethyl)-31,75-bis(2-carboxyethyl)-72-(carboxymethyl)-22,45,57-tris(1-hydroxyethyl)-10-(hydroxymethyl)-69-[(4-hydroxyphenyl)methyl]-54-[(1H-indol-3-yl)methyl]-78-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,23,26,29,32,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,90,93,96,99,105,112-dotriacontaoxo-36,37,86,87,108,109,114,115-octathia-3,6,9,12,15,18,21,24,27,30,33,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82,91,94,97,100,106,111-dotriacontaazapentacyclo[58.46.4.4⁷,²⁸.2³⁹,⁸⁹.0¹⁰⁰,¹⁰⁴]116n-84-yl]carbamoyl}-2-carbamoylethyl)carbamoyl]-2-carboxyethyl}carbamoyl)butanoic acid

Smiles: CC(CC)C1NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C2CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)CNC1=O)C(C)O)C(=O)NC(CCC(O)=O)C(=O)NC(CSSCC1NC(=O)C(CCCCN)NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(CC3=CNC4=CC=CC=C34)NC(=O)C(NC(=O)C3CSSCC(NC(=O)C4CCCN4C(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(N)CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC4C=CC(O)=CC=4)C(=O)NCC(=O)NC(CCCCN)C(=O)N3)NC1=O)C(=O)NC(CCCNC(N)=N)C(=O)N2)C(C)O)C(C)O)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CC1C=CC=CC=1)C(=O)NC(C)C(O)=O

InChiKey: MBXCGHHUBOKUGG-UHFFFAOYSA-N

InChi: InChI=1S/C215H337N65O70S10/c1-19-101(8)163-203(341)239-88-156(295)273-167(107(14)284)207(345)261-134(79-150(220)289)187(325)268-139-91-353-355-93-141(196(334)263-137(89-281)191(329)250-126(62-72-352-18)183(321)274-163)264-179(317)120(44-32-66-230-213(223)224)247-195(333)143-95-357-359-97-145-199(337)277-168(108(15)285)208(346)260-132(77-112-82-233-116-40-26-25-39-114(112)116)175(313)235-83-151(290)234-84-155(294)272-166(106(13)283)206(344)252-119(42-28-30-64-217)178(316)265-142(94-356-360-98-146(267-181(319)124(249-194(139)332)56-60-160(302)303)200(338)278-169(109(16)286)210(348)280-70-36-48-148(280)201(339)251-121(45-33-67-231-214(225)226)177(315)255-129(74-100(6)7)190(328)275-165(103(10)21-3)205(343)253-125(61-71-351-17)182(320)248-122(54-58-158(298)299)173(311)237-87-154(293)244-128(73-99(4)5)185(323)262-138(90-282)192(330)257-131(75-110-37-23-22-24-38-110)184(322)241-105(12)211(349)350)197(335)270-140(193(331)246-117(43-31-65-229-212(221)222)172(310)236-86-153(292)243-127(46-34-68-232-215(227)228)209(347)279-69-35-47-147(279)202(340)271-143)92-354-358-96-144(269-186(324)133(78-149(219)288)258-188(326)135(80-161(304)305)254-171(309)115(218)53-57-157(296)297)198(336)276-164(102(9)20-2)204(342)240-104(11)170(308)245-123(55-59-159(300)301)180(318)259-136(81-162(306)307)189(327)256-130(76-111-49-51-113(287)52-50-111)174(312)238-85-152(291)242-118(176(314)266-145)41-27-29-63-216/h22-26,37-40,49-52,82,99-109,115,117-148,163-169,233,281-287H,19-21,27-36,41-48,53-81,83-98,216-218H2,1-18H3,(H2,219,288)(H2,220,289)(H,234,290)(H,235,313)(H,236,310)(H,237,311)(H,238,312)(H,239,341)(H,240,342)(H,241,322)(H,242,291)(H,243,292)(H,244,293)(H,245,308)(H,246,331)(H,247,333)(H,248,320)(H,249,332)(H,250,329)(H,251,339)(H,252,344)(H,253,343)(H,254,309)(H,255,315)(H,256,327)(H,257,330)(H,258,326)(H,259,318)(H,260,346)(H,261,345)(H,262,323)(H,263,334)(H,264,317)(H,265,316)(H,266,314)(H,267,319)(H,268,325)(H,269,324)(H,270,335)(H,271,340)(H,272,294)(H,273,295)(H,274,321)(H,275,328)(H,276,336)(H,277,337)(H,278,338)(H,296,297)(H,298,299)(H,300,301)(H,302,303)(H,304,305)(H,306,307)(H,349,350)(H4,221,222,229)(H4,223,224,230)(H4,225,226,231)(H4,227,228,232)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.