(+)-SHIN1

(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1.

Product information

CAS Number: 2443966-90-1

Molecular Weight: 400.47

Formula: C24H24N4O2

Chemical Name: (4S)-6-amino-4-[5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl]-3-methyl-4-(propan-2-yl)-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile

Smiles: CC1NN=C2OC(N)=C(C#N)[C@@](C(C)C)(C=12)C1C=C(CO)C=C(C=1)C1C=CC=CC=1

InChiKey: VVVOFJZXKJKHTD-DEOSSOPVSA-N

InChi: InChI=1S/C24H24N4O2/c1-14(2)24(20(12-25)22(26)30-23-21(24)15(3)27-28-23)19-10-16(13-29)9-18(11-19)17-7-5-4-6-8-17/h4-11,14,29H,13,26H2,1-3H3,(H,27,28)/t24-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (249.71 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively.

Products are for research use only. Not for human use.