Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution.
CDK9-IN-1
From $95
CDK9-IN-10
$7,000
CDK9-IN-2
From $125
CDKI-73
From $105
CGP60474
From $103
CKI-7
$100
CKI-7 free base
From $125
CP-10, PROTAC for CDK6
From $450
CVT-313
From $83
DD-03-156
$100
Desmethylglycitein
From $321
Dinaciclib
From $95
DRB
$100
Flavopiridol (Alvocidib)
From $100
Flavopiridol Hydrochloride
From $95
FMF-04-159-2
From $118
Glucocorticoid receptor agonist
From $155
HQ461
$100
hSMG-1 inhibitor 11j
From $440
Indirubin-3'-monoxime-5-sulphonic acid
From $2,390
JNJ-7706621
From $100
K 03861
From $134