MK-3207 Hydrochloride

MK-3207 is a potent and orally active calcitonin gene-related peptide receptor antagonist. Calcitonin gene related peptide (CGRP) receptor antagonists are effective acute migraine treatments. (Ki = 0.024 nM).

Product information

CAS Number: 957116-20-0

Molecular Weight: 594.05

Formula: C31H30ClF2N5O3

Synonym:

MK3207 Hydrochloride

MK 3207 Hydrochloride

MK-3207

Chemical Name: 2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-6-yl]acetamide hydrochloride

Smiles: Cl.O=C(CN1[C@@H](CNC2(CCCC2)C1=O)C1C=C(F)C=C(F)C=1)NC1=CC2C[C@]3(CC=2C=C1)C1=CC=CN=C1NC3=O

InChiKey: VWKNXYACOMQRBX-KZCKSIIFSA-N

InChi: InChI=1S/C31H29F2N5O3.ClH/c32-21-10-19(11-22(33)13-21)25-16-35-31(7-1-2-8-31)29(41)38(25)17-26(39)36-23-6-5-18-14-30(15-20(18)12-23)24-4-3-9-34-27(24)37-28(30)40;/h3-6,9-13,25,35H,1-2,7-8,14-17H2,(H,36,39)(H,34,37,40);1H/t25-,30+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Li CC, Vermeersch S, Denney WS, Kennedy WP, Palcza J, Gipson A, Han TH, Blanchard R, De Lepeleire I, Depré M, Murphy MG, Van Dyck K, de Hoon JN. Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist. Br J Clin Pharmacol. 2015 May;79(5):831-7.
2. Hewitt DJ, Aurora SK, Dodick DW, Goadsby PJ, Ge YJ, Bachman R, Taraborelli D, Fan X, Assaid C, Lines C, Ho TW. Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine. Cephalalgia. 2011 Apr;31(6):712-22.

Products are for research use only. Not for human use.