Folic acid

ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).

Product information

CAS Number: 59-30-3

Molecular Weight: 449.46

Formula: C19H27N7O6

Chemical Name: (2S)-2-[(4-{[(2-amino-4-oxo-decahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

Smiles: NC1NC2NCC(CNC3C=CC(=CC=3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)NC2C(=O)N1

InChiKey: HUKMMLFXQPOBCR-AMEPKZMBSA-N

InChi: InChI=1S/C19H27N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,14-15,19,21-23,25H,5-8,20H2,(H,24,29)(H,26,30)(H,27,28)(H,31,32)/t11?,12-,14?,15?,19?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.