SAN50900

SAN50900, also known as FLT3-IN-3, is a potent and selective FLT3 inhibitor. SAN50900 displays nanomolar activity in biochem. assays and selectively blocks proliferation of AML cell lines harboring FLT3-​ITD mutations, whereas other transformed and normal human cells are several orders of magnitude less sensitive. SAN50900 was first reported in J Med Chem. 2018 May 10;61(9):3855-3869. (compd. 7d).

Product information

CAS Number: 2229050-90-0

Molecular Weight: 490.64

Formula: C27H38N8O

Synonym:

FLT3-IN-3

FLT3-IN3

Chemical Name: N2-((1r, 4r)-4-aminocyclohexyl)-9-cyclopentyl-N6-(4-(morpholinomethyl)phenyl)-9H-purine-2, 6-diamine

Smiles: N[C@@H]1CC[C@H](CC1)NC1N=C(NC2C=CC(CN3CCOCC3)=CC=2)C2N=CN(C3CCCC3)C=2N=1

InChiKey: SAEGVASGMTZGFI-AQYVVDRMSA-N

InChi: InChI=1S/C27H38N8O/c28-20-7-11-22(12-8-20)31-27-32-25(24-26(33-27)35(18-29-24)23-3-1-2-4-23)30-21-9-5-19(6-10-21)17-34-13-15-36-16-14-34/h5-6,9-10,18,20,22-23H,1-4,7-8,11-17,28H2,(H2,30,31,32,33)/t20-,22-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.