Description
Alobresib, also known as GS-5829, is a potent and selective BET inhibitor. GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. GS-5829 inhibited CLL cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. IκBα modulation indicates that GS-5829 also inhibited NF-κB signaling. GS-5829-induced apoptosis resulted from an imbalance between positive (BIM) and negative regulators (BCL-XL) of the intrinsic apoptosis pathway.
Product information
CAS Number: 68-41-7
Molecular Weight: 102.09
Formula: C3H6N2O2
Chemical Name: (4R)-4-amino-1,2-oxazolidin-3-one
Smiles: N[C@@H]1CONC1=O
InChiKey: DYDCUQKUCUHJBH-UWTATZPHSA-N
InChi: InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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