THI0019

THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC50 range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2.

Product information

CAS Number: 1378532-99-0

Molecular Weight: 601.73

Formula: C29H35N3O7S2

Chemical Name: methyl (3S)-3-(2H-1,3-benzodioxol-5-yl)-3-({[(2S)-1-({bis[(thiophen-2-yl)methyl]carbamoyl}oxy)hexan-2-yl]carbamoyl}amino)propanoate

Smiles: COC(=O)C[C@H](NC(=O)N[C@H](COC(=O)N(CC1=CC=CS1)CC1=CC=CS1)CCCC)C1=CC2OCOC=2C=C1

InChiKey: QWDGYRDMZTZEHQ-URXFXBBRSA-N

InChi: InChI=1S/C29H35N3O7S2/c1-3-4-7-21(18-37-29(35)32(16-22-8-5-12-40-22)17-23-9-6-13-41-23)30-28(34)31-24(15-27(33)36-2)20-10-11-25-26(14-20)39-19-38-25/h5-6,8-14,21,24H,3-4,7,15-19H2,1-2H3,(H2,30,31,34)/t21-,24-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 240 mg/mL (398.85 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC50 of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC50 of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC50 of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α.

Products are for research use only. Not for human use.