RCGD423

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

Product information

CAS Number: 108237-91-8

Molecular Weight: 331.23

Formula: C15H11BrN2S

Chemical Name: N-(4-Bromophenyl)-4-phenyl-1,3-thiazol-2-amine

Smiles: BrC1C=CC(=CC=1)NC1=NC(=CS1)C1C=CC=CC=1

InChiKey: OUFYYVAASPLOAA-UHFFFAOYSA-N

InChi: InChI=1S/C15H11BrN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 160 mg/mL (483.05 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

In Vivo:

RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage.

References:

1. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.

Products are for research use only. Not for human use.