Dihydrorotenone

Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

Product information

CAS Number: 6659-45-6

Molecular Weight: 396.43

Formula: C23H24O6

Chemical Name: (1S, 6R, 13S)-16, 17-dimethoxy-6-(propan-2-yl)-2, 7, 20-trioxapentacyclo[11.8.0.0, .0, .0, ]henicosa-3, 8, 10, 14, 16, 18-hexaen-12-one

Smiles: CC(C)[C@H]1CC2=C(C=CC3C(=O)[C@@H]4[C@@H](COC5=CC(OC)=C(C=C54)OC)OC2=3)O1

InChiKey: DTFARBHXORYQBF-HBGVWJBISA-N

InChi: InChI=1S/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911.

Products are for research use only. Not for human use.