Description
CCI-006 is a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias, inhibiting mitochondrial respiration and inducing mitochondrial membrane depolarization and apoptosis in a subset (7/11, 64%) of MLL-rearranged leukemia cell lines within a few hours of treatment.
Product information
CAS Number: 292053-42-0
Molecular Weight: 332.33
Formula: C15H12N2O5S
Chemical Name: methyl (E)-2-cyano-3-(5-(4-sulfamoylphenyl)furan-2-yl)acrylate
Smiles: COC(=O)/C(=C/C1=CC=C(O1)C1=CC=C(C=C1)S(N)(=O)=O)/C#N
InChiKey: VEXAKEBSBMAIOB-DHZHZOJOSA-N
InChi: InChI=1S/C15H12N2O5S/c1-21-15(18)11(9-16)8-12-4-7-14(22-12)10-2-5-13(6-3-10)23(17,19)20/h2-8H,1H3,(H2,17,19,20)/b11-8+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 83.33 mg/mL (250.74 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
Products are for research use only. Not for human use.
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