Description
SPS-4251, also known as AS-77 and PAP-1, is a KCNA3 (Potassium voltage-gated channel, shaker-related subfamily, member 3) channel blocker potentially for the treatment of plaque psoriasis. Kv1.3 channels regulate the activation/proliferation of effector memory T cells and thus play a critical role in the pathogenesis of autoimmune diseases. PAP-1 reduced the secretion of TNFα by adipose tissue but had no effect on the secretion of IL-6. PAP-1 can also potentially inhibit the exocytosis of cytoplasmic granules from CD4(+)CD28(null) T cells.
Product information
CAS Number: 870653-45-5
Molecular Weight: 350.36
Formula: C21H18O5
Chemical Name: 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one
Smiles: O=C1C=CC2C(OCCCCOC3C=CC=CC=3)=C3C=COC3=CC=2O1
InChiKey: KINMYBBFQRSVLL-UHFFFAOYSA-N
InChi: InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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