Almitrine mesylate

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.

Product information

CAS Number: 29608-49-9

Molecular Weight: 669.76

Formula: C28H37F2N7O6S2

Synonym:

Vectarion

Almitrin

Almitrina

Almitrinum

Related CAS Number:

27469-53-0 (Almitrine (free base))

Chemical Name: 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-N,N'-diprop-2-enyl-1,3,5-triazine-2,4-diamine

Smiles: CS(O)(=O)=O.CS(O)(=O)=O.C=CCNC1N=C(N=C(NCC=C)N=1)N1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1

InChiKey: MRDBGMJEPGXQHJ-UHFFFAOYSA-N

InChi: InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(149.3 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. J R López-López, et al. Mol Pharmacol. 1998 Feb;53(2):330-9.
2. P D Smith, et al. Drug Intell Clin Pharm. 1987 May;21(5):417-21.

Products are for research use only. Not for human use.