α-2, 3-sialyltransferase-IN-1

α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM.

Product information

CAS Number: 881179-06-2

Molecular Weight: 491.66

Formula: C28H45NO6

Synonym:

Lith-O-Asp analog

Chemical Name: (4R)-4-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-{[(2R)-2-amino-3-carboxypropanoyl]oxy}-1,3a,3b,5a,9b-pentahydrogenio-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid

Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3CC[C@@]21C)OC(=O)[C@H](N)CC(O)=O

InChiKey: NUUCRVJEHQBAKP-GCHQISOYSA-N

InChi: InChI=1S/C28H45NO6/c1-16(4-9-24(30)31)20-7-8-21-19-6-5-17-14-18(35-26(34)23(29)15-25(32)33)10-12-27(17,2)22(19)11-13-28(20,21)3/h16-23H,4-15,29H2,1-3H3,(H,30,31)(H,32,33)/t16-,17-,18-,19+,20-,21+,22+,23-,27+,28-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 103.7 mg/mL (210.92 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

α-2,3-sialyltransferase-IN-1 is compound 17 in the reference.

References:

1. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.

Products are for research use only. Not for human use.