Description
Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery. It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea. Lacidipine induces negative inotropy in isolated guinea pig ventricular strips. It reduces mean blood pressure in spontaneously hypertensive rats and in renal hypertensive dogs with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.
Product information
CAS Number: 103890-78-4
Molecular Weight: 455.54
Formula: C26H33NO6
Chemical Name: 3,5-diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Smiles: CC(C)(C)OC(=O)/C=C/C1=CC=CC=C1C1C(C(=O)OCC)=C(C)NC(C)=C1C(=O)OCC
InChiKey: GKQPCPXONLDCMU-CCEZHUSRSA-N
InChi: InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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