Taxifolin

Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

Product information

CAS Number: 480-18-2

Molecular Weight: 304.25

Formula: C15H12O7

Synonym:

Taxifoliol

Lariksin

Lavitol

Catechin hydrate

Dihydroquercetin

Chemical Name: (2R, 3R)-2-(3, 4-dihydroxyphenyl)-3, 5, 7-trihydroxy-3, 4-dihydro-2H-1-benzopyran-4-one

Smiles: O[C@@H]1[C@H](OC2=CC(O)=CC(O)=C2C1=O)C1=CC(O)=C(O)C=C1

InChiKey: CXQWRCVTCMQVQX-LSDHHAIUSA-N

InChi: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 60 mg/mL(197.2 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Taxifolin is not mutagenic and low toxic compared to Qercetin. It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.

References:

1. Luo H, et al. Nutr Cancer, 2008, 60(6), 800-809.
2. Lee SB, et al. Biol Pharm Bull, 2007, 30(6), 1074-1079.
3. Makena PS, et al. Environ Mol Mutagen, 2009, 50(6), 451-459.

Products are for research use only. Not for human use.