Novel and highly potent neuro-protective molecule P7C3
Oct 13,2014 03:55 | news
Just published in last month Cell, recent MOA study of the neuro-protective small moleculeP7C3, which has broad in vitro and in vivo activities, offers new exciting opportunities in studying neurological diseases, injuries, development, and degenerative diseases in other tissues sharing common mechanisms.
P7C3 is a nontoxic, stable, and orally bioavailable synthetic small molecule identified directly from an in vivo neurogenesis screening. It can protect newborn neurons in the dentate gyrus and stimulates the growth of new neurons. It can also enhance learning and memory in aged rats. P7C3 can also preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme involved in the conversion of nicotinamide into nicotinamide adenine dinucleotide (NAD). Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity.
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