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Apoptosis related

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  1. ABT-199, BCL-2 inhibitor

    Catalog No. M60075
    A potent BCL-2–selective (BCL-X L) inhibitor with clinical efficacy.
  2. BAM7, BAX Activator

    Catalog No. M60069
    The first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member.
  3. Bioymifi, TRAIL Receptor DR5 Activator

    Catalog No. M60088
    A potent and selective small molecule agonist of DR5.
  4. CI994 (Tacedinaline), HDAC Inhibitor

    Catalog No. M60186
    A potent, selective and orally active histone deacetylase (HDAC) inhibitor targeting HDAC1, HDAC2 and HDAC3.
  5. EPZ-6438, EZH2 Methyltransferase Inhibitor

    Catalog No. M60122
    EPZ-6438 (E7438) is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 in clinical development.
  6. Ferrostatin-1 (Fer-1), Ferroptosis Inhibitor

    Catalog No. M60042
    Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells.
  7. LDN-57444, Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor

    Catalog No. M60204
    A novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1).
  8. MHY1485, mTOR Activator

    Catalog No. M60189
    A novel potent, selective and cell-permeable mTOR activator.
  9. MK-1775 (AZD1775), WEE1 Inhibitor

    Catalog No. M60299
    A highly potent, selective and orally bioavailable Wee1 kinase inhibitor.
  10. NMS-859, ATPase VCP/p97 Inhibitor

    Catalog No. M60148
    A potent and specific small molecule covalent inhibitor of the ATPase VCP/p97.
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