BI-7273, BRD9 Bromodomain Inhibitor

BI-7273 is a potent and selective BRD9 inhibitor. BI-7273 may be useful in further exploring BRD9 bromodomain biology in both in vitro and in vivo settings. Selective inhibitors of bromodomain-containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignancies and inflammatory diseases.

Product information

CAS Number: 1883429-21-7

Molecular Weight: 353.41

Formula: C20H23N3O3

Chemical Name: 4-(4-((dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

Smiles: CN(C)CC1C(=CC(=CC=1OC)C1=CN(C)C(=O)C2=CN=CC=C12)OC

InChiKey: RBUYFHLQNPJMQM-UHFFFAOYSA-N

InChi: InChI=1S/C20H23N3O3/c1-22(2)11-17-18(25-4)8-13(9-19(17)26-5)16-12-23(3)20(24)15-10-21-7-6-14(15)16/h6-10,12H,11H2,1-5H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM; Water up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

BI-7273 was used at 1-10 µM in vitro and cellular assays.

In Vivo:

BI-7273 was orally dosed to mice at 180 mg/kg once per day.

References:

1. Martin LJ, et al. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. (2016) J Med Chem. 59(10):4462-75.

Products are for research use only. Not for human use.

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