SMER3 --- SCF family E3 Ubiquitin Ligase Inhibitor

SMER3 is a small molecule enhancer of rapamycin (SMER). It is also a specific inhibitor of Ubiquitin E3 ligase.

Product information

CAS Number: 67200-34-4

Molecular Weight: 224.18

Formula: C11H4N4O2

Chemical Name: 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

Smiles: O=C1C2=NC3=NON=C3N=C2C2=CC=CC=C21

InChiKey: SFSSAKVWCKFRHE-UHFFFAOYSA-N

InChi: InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SMER3 was used at 10-20 µM final concentration in various in vitro assays.

References:

1. Aghajan M, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. (2010) Nat Biotechnol. 28(7):738-42.

Products are for research use only. Not for human use.

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