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Wnt pathway

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Items 1 to 10 of 12 total

  1. CHIR99021, GSK3β Inhibitor

    Catalog No. M60002
    The most widely used, potent and selective GSK3β Inhibitor; Wnt pathway activator.
  2. HLY78, Wnt Activator

    Catalog No. M60140
    An activator of the Wnt pathway by targeting the DIX domain of Axin and potentiating the Axin–LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
  3. ID-8, DYRK Inhibitor

    Catalog No. M60102
    A potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation- regulated kinase (DYRK).
  4. IWP-2, Porcupine (Wnt) Inhibitor

    Catalog No. M60115
    A potent and highly selective Wnt signaling antagonist targeting porcupine.
  5. KY02111, Wnt Inhibitor

    Catalog No. M60073
    A potent and selective Wnt inhibitor promotes differentiation of hESCs/iPSCs to cardiomyocytes; might function downstream from GSK3β and APC in b-catenin destruction complex
  6. KYA1797K, Wnt/β-catenin Inhibitor

    Catalog No. M60317
    A highly potent and selective Wnt/β-catenin inhibitor binding directly to the regulators of G-protein signaling domain of axin.
  7. LGK974, Porcupine (Wnt) Inhibitor

    Catalog No. M60106
    A highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) in clinical trials.
  8. MSAB, β-catenin Inhibitor

    Catalog No. M60316
    A potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening.
  9. NVP-TNKS656, Wnt / Tankyrase Inhibitor

    Catalog No. M60328
    A highly potent, selective and oral bioavailable tankyrase inhibitor for TNKS2.
  10. WAY-316606, Secreted Frizzled-related Protein-1 (sFRP-1) Inhibitor

    Catalog No. M60215
    A novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) to increase Wnt signaling.
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