Description
Bafilomycin D is a potent inhibitor of vacuolar H+ ATPases (V-ATPases) with IC50 value of approximately 2 nM for the V-ATPase from the fungus N. crassa . Ion pumps use the energy provided by the hydrolysis of ATP to energize ion-transport processes across cell membranes. ATPases can be distinguished to P-type, F-type and V-type ATPases. P-type ATPases have a phosphorylated transitional stage, F-type ATPases are primarily used in ATP synthesis, and V-type ATPases are genetically and functionally related to F-ATPases but function only in ATP breakdown . The bafilomycins are fungal plecomacrolide class macrolide antibiotics isolated from the culture medium of Streptomyces sp. and are also high-affinity inhibitors of V-ATPases and can be used to study specifically the function of this type of ATPase. They inhibited the growth of Gram-positive bacteria and fungi. Bafilomycin C1 inhibited the enzymatic activity of the Na+, K+-ATPase with Ki value of 11 μmol/l and showed anthelmintic activity against Caenorhabditis elegans .
Product information
CAS Number: 98813-13-9
Molecular Weight: 604.81
Formula: C35H56O8
Chemical Name: (7R,8S,9S,15S,16R)-16-[(2S,3R,4S,6E,8S,9R)-3,9-dihydroxy-4,8,10-trimethyl-5-oxoundec-6-en-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Smiles: CC(C)[C@@H](O)[C@@H](C)/C=C/C(=O)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)C(=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C[C@@H]1OC)OC |t:21,24,34,36|
InChiKey: ZKOTUWJMGBWBEO-HLACIFKFSA-N
InChi: InChI=1S/C35H56O8/c1-20(2)31(37)23(5)15-16-28(36)26(8)33(39)27(9)34-29(41-10)14-12-13-21(3)17-24(6)32(38)25(7)18-22(4)19-30(42-11)35(40)43-34/h12-16,18-20,23-27,29,31-34,37-39H,17H2,1-11H3/b14-12-,16-15+,21-13-,22-18-,30-19+/t23-,24-,25+,26+,27-,29-,31+,32-,33-,34+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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