Amoxicillin (trihydrate)

Amoxicillin Trihydrate is a broad-spectrum antibiotic. It binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivated PBP interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

Product information

CAS Number: 61336-70-7

Molecular Weight: 419.45

Formula: C16H25N3O8S

Synonym:

Amoxycillin trihydrate

Amoxil trihydrate

Chemical Name: (2S,5R,6R)-6-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrate

Smiles: O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3C=CC(O)=CC=3)C(=O)N2[C@H]1C(O)=O

InChiKey: MQXQVCLAUDMCEF-CWLIKTDRSA-N

InChi: InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (23.84 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Poapolathep S, Giorgi M, Klangkaew N, Phaochoosak N, Chaiyabutr N, Wongwaipairoj T, Poapolathep A. Pharmacokinetic profiles of amoxicillin trihydrate in freshwater crocodiles (Crocodylus siamensis) after intramuscular administration at two doses. J Vet Pharmacol Ther. 2020 Jul;43(4):307-312.
2. Thambavita D, Galappatthy P, Mannapperuma U, Jayakody L, Cristofoletti R, Abrahamsson B, Groot DW, Langguth P, Mehta M, Parr A, Polli JE, Shah VP, Dressman J. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate. J Pharm Sci. 2017 Oct;106(10):2930-2945.

Products are for research use only. Not for human use.