BAY-1251152 racemate

BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.

Product information

CAS Number: 1610358-53-6

Molecular Weight: 404.43

Formula: C19H18F2N4O2S

Synonym:

BAY-1251152 racemate

BAY1251152

BAY 1251152

(±)-BAY-1251152

((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

Related CAS Number:

1610358-56-9 ((+)​BAY-1251152)

1610358-59-2 ((-​)​BAY-1251152)

1610368-59-6 ((R)BAY-1251152 HCl)

1610408-96-2 ((R)BAY-1251152)

1610408-97-3 ((S)(R)BAY-1251152)

1610368-60-9 ((S)BAY-1251152 HCl)

Chemical Name: 2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-

Smiles: COC1=CC(F)=CC=C1C1=CC(NC2=CC(CS(C)(=N)=O)=CC=N2)=NC=C1F

InChiKey: YZCUMZWULWOUMD-UHFFFAOYSA-N

InChi: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)

Technical Data

Appearance: Solid powder

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 50mg/mL

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0-4^oC for short term (days to weeks) or -20^oC for long term (months to years).

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0-4^oC for short term (days to weeks), or -20^oC for long term (months).

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

References:

1. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984.

Products are for research use only. Not for human use.