Alsterpaullone


Catalog No. Size PriceQuantity
M7397-2 2mg solid $100
M7397-10 10mg solid $340
M7397-100 100mg solid $2,280

Description

Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.

Product information

CAS Number: 237430-03-4

Molecular Weight: 293.28

Formula: C16H11N3O3

Chemical Name: 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

Smiles: [O-][N+](=O)C1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C43)C2=C1

InChiKey: OLUKILHGKRVDCT-UHFFFAOYSA-N

InChi: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Tyler Lahusen, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
  2. M Leost, et al. Eur J Biochem. 2000 Oct;267(19):5983-94.

Products are for research use only. Not for human use.

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