RU.521


Catalog No. Size PriceQuantity
M30923-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 700 nM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

Product information

CAS Number: 2262452-06-0

Molecular Weight: 415.23

Formula: C19H12Cl2N4O3

Chemical Name: 2-(4,5-dichloro-1H-1,3-benzodiazol-2-yl)-5-methyl-4-(3-oxo-1,3-dihydro-2-benzofuran-1-yl)-2,3-dihydro-1H-pyrazol-3-one

Smiles: CC1NN(C2NC3=CC=C(Cl)C(Cl)=C3N=2)C(=O)C=1C1OC(=O)C2=CC=CC=C21

InChiKey: IAWZUQAOMURCLV-UHFFFAOYSA-N

InChi: InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,24H,1H3,(H,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (301.04 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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