FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.
CAS Number: 1569076-11-4
Molecular Weight: 385.34
US10208043, # 2
Chemical Name: N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide
Appearance: Power Solid
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Powder: 4oC 1 year.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: DMSO: 4oC 3 month
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
FASCIN-G2 was usually used at 10-50 µM final concentration in vitro.
FASCIN-G2 was dosed to mice by intraperitoneal injection at 100 mg/Kg once per day in 4T1 mammary tumour metastasis model or in MDA-MB-231 human breast tumour metastasis model.
- Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. (2015) Nat Commun. 6:7465.
Products are for research use only. Not for human use.
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