FASCIN-G2, Fascin Inhibitor


Catalog No. size PriceQuantity
M60269-2S 2 mg solid $129
M60269-10S 10 mg solid $516

Description

FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.

Product information

CAS Number: 1569076-11-4

Molecular Weight: 385.34

Formula: C20H14F3N3O2

Synonym:

US10208043, # 2

N-[1-[[4-(trifluoromethyl)phenyl]methyl]indazol-3-yl]furan-2-carboxamide

N-[1-[[4-(Trifluoromethyl)phenyl]methyl]-1H-indazol-3-yl]-2-furancarboxamide

Chemical Name: N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide

Smiles: O=C(NC1=NN(CC2C=CC(=CC=2)C(F)(F)F)C2=CC=CC=C21)C1=CC=CO1

InChiKey: LWBFIOPAFDTCND-UHFFFAOYSA-N

InChi: InChI=1S/C20H14F3N3O2/c21-20(22,23)14-9-7-13(8-10-14)12-26-16-5-2-1-4-15(16)18(25-26)24-19(27)17-6-3-11-28-17/h1-11H,12H2,(H,24,25,27)

Technical Data

Appearance: Power Solid

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Powder: 4oC 1 year.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: DMSO: 4oC 3 month

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

FASCIN-G2 was usually used at 10-50 µM final concentration in vitro.

In Vivo:

FASCIN-G2 was dosed to mice by intraperitoneal injection at 100 mg/Kg once per day in 4T1 mammary tumour metastasis model or in MDA-MB-231 human breast tumour metastasis model.

References:

  1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. (2015) Nat Commun. 6:7465.

Products are for research use only. Not for human use.

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