Description
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
Product information
CAS Number: 916151-99-0
Molecular Weight: 367.38
Formula: C22H14FN5
Chemical Name: 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
Smiles: CC1NC2=CC=C(F)C=C2C=1C1NC2=C(N=1)C1=CC=CN=C1C1=NC=CC=C21
InChiKey: NIRXBXIPHUTNNI-UHFFFAOYSA-N
InChi: InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 73 mg/mL(198.7 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Baojin Wang, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.
- Andrea Local, et al. Mol Cancer Ther. 2018 Jun;17(6):1177-1186.
Products are for research use only. Not for human use.
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