Description
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136).
Product information
CAS Number: 2101200-10-4
Molecular Weight: 371.43
Formula: C23H21N3O2
Chemical Name: 6-(3, 5-dimethyl-1, 2-oxazol-4-yl)-1-methyl-4-phenyl-3-(prop-2-yn-1-yl)-1, 2, 3, 4-tetrahydroquinazolin-2-one
Smiles: CN1C(=O)N(CC#C)C(C2=CC(=CC=C12)C1=C(C)ON=C1C)C1=CC=CC=C1
InChiKey: ZKJVDZJHVLJOKO-UHFFFAOYSA-N
InChi: InChI=1S/C23H21N3O2/c1-5-13-26-22(17-9-7-6-8-10-17)19-14-18(21-15(2)24-28-16(21)3)11-12-20(19)25(4)23(26)27/h1,6-12,14,22H,13H2,2-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1.
References:
- Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
Products are for research use only. Not for human use.
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