GR-103545 fumarate

GR-103545 is a reference and non-radio labeled agent. The radio-labeled 11C-GR103545 is a promising PET radiotracer for imaging the κ-OR.

Product information

CAS Number: 126766-43-6

Molecular Weight: 530.40

Formula: C23H29Cl2N3O7

Chemical Name: (2E)-but-2-enedioic acid; methyl (3R)-4-[2-(3, 4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate

Smiles: COC(=O)N1C[C@@H](CN2CCCC2)N(CC1)C(=O)CC1=CC(Cl)=C(Cl)C=C1.OC(=O)/C=C/C(O)=O

InChiKey: ABTNETSDXZBJTE-WMQZXYHMSA-N

InChi: InChI=1S/C19H25Cl2N3O3.C4H4O4/c1-27-19(26)23-8-9-24(15(13-23)12-22-6-2-3-7-22)18(25)11-14-4-5-16(20)17(21)10-14;5-3(6)1-2-4(7)8/h4-5,10,15H,2-3,6-9,11-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t15-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Vanz F, Bicca MA, Linartevichi VF, Giachero M, Bertoglio LJ, Monteiro de Lima TC. Role of dorsal hippocampus κ opioid receptors in contextual aversive memory consolidation in rats. Neuropharmacology. 2018 Jun;135:253-267. doi: 10.1016/j.neuropharm.2018.02.029. Epub 2018 Feb 27. PMID: 29499274.
2. Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ. Kappa opioid receptor binding in major depression: A pilot study. Synapse. 2018 Sep;72(9):e22042. doi: 10.1002/syn.22042. Epub 2018 Jul 17. PMID: 29935119; PMCID: PMC7599086.

Products are for research use only. Not for human use.