Phospho-HDAC4 (Ser632) Antibody


Catalog No. size PriceQuantity
A90009-100 100 ul $402

Description

Product Information

 

Clonality: Polyclonal Source: Rabbit  
Applications: WB: 1:500-1:2000 Cross-Reactivity: H   M   Rat  
Concentration: 100 ug/100 ul Detected band  (by western) MW: 119kDa  
   

Alt. Names

HA6116; HD4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288

Specificity:

Phospho-HDAC4 (Ser632) Antibody detects endogenous levels of HDAC4 only when phosphorylated at Serine 632

Immunogen:

A synthesized peptide derived from human HDAC4 around the phosphorylation site of Serine 632

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.



Background:

Histone deacetylase 4 (HDAC4) is a histone deacetylase that represses transcription when tethered to a promoter.  It has been shown to interact with MEF2C, Zinc finger, CBX5, Nuclear receptorco-repressor1 and HDAC3 (1, 2, 3, 4, 5).  In neurological findings, HDAC4 has been shown to shuttle between the nucleus and cytoplasm, controlling a transcriptional program essential for synaptic plasticity and memory.  The nuclear import of HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength (6). 

 Please refer PDF file for Western, Immunofluorescence analysis,  Chromatin immunoprecipitation analysis or other QC data. 


Reference: 
  1. Wang, A H et al.  HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressors. (1999) Mol. Cell. Biol (UNITED STATES) 19 (11): 7816–27.
  2. Anne C et al. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". (2004) Oncogene (England) 23 (54): 8777–84.
  3. Olson E N et al. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. (2002) Mol. Cell. Biol. (United States) 22 (20): 7302–12.
  4. Wolfgang F et al. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". (2002) Mol. Cell (United States) 9 (1): 45–57.
  5. Fischle, W et al. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (2001) J. Biol. Chem. (United States) 276
  6. Sando, R et al. HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory. (2012) Cell. 151 (4): 821-834. 



Product is for research use only. Not for human use.

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