Super-TDU (1-31) (TFA)

Super-TDU (1-31) is a peptide of Super-TDU, which is an inhibitor of YAP-TEADs, shows potent anti-tumor activity.

Product information

Molecular Weight: 3355.50

Formula: C143H219F3N40O50

Chemical Name: (3S, 9S, 12S, 15S, 18R, 21S, 24S, 27S, 30S)-24-((1H-imidazol-5-yl)methyl)-3-((3S, 9S, 18S, 21S, 24S, 27S, 30S, 31S)-27-((1H-indol-3-yl)methyl)-1-amino-3-((S)-2-((3S, 6S, 9R, 12S, 15S)-19-amino-3-((S)-2-((S)-5-amino-1-((1S, 2S)-1-carboxy-2-hydroxypropylamino)-1, 5-dioxopentan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)-6-(2-amino-2-oxoethyl)-12-((S)-1-hydroxyethyl)-2, 9-dimethyl-5, 8, 11, 14-tetraoxo-4, 7, 10, 13-tetraazanonadecan-15-ylcarbamoyl)pyrrolidine-1-carbonyl)-21-(3-amino-3-oxopropyl)-18-sec-butyl-31-hydroxy-9-(hydroxymethyl)-24-isobutyl-1, 5, 8, 11, 14, 17, 20, 23, 26, 29-decaoxo-4, 7, 10, 13, 16, 19, 22, 25, 28-nonaazadotriacontan-30-ylcarbamoyl)-30-((S)-2-((S)-2-amino-3-hydroxypropanamido)-3-methylbutanamido)-15-(4-aminobutyl)-21-benzyl-27-(carboxymethyl)-12-(hydroxymethyl)-9-isobutyl-18-methyl-5, 8, 11, 14, 17, 20, 23, 26, 29-nonaoxo-4, 7, 10, 13, 16, 19, 22, 25, 28-nonaazadotriacontane-1, 32-dioic acid compound with 2, 2, 2-trifluoroacetic acid (1:1)

Smiles: CC[C@@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@H](C)O)C(O)=O.OC(=O)C(F)(F)F

InChiKey: OSKJKOAHQPZHGY-VLKIPGASSA-N

InChi: InChI=1S/C141H218N40O48.C2HF3O2/c1-16-68(10)111(135(222)154-56-102(192)151-57-103(193)160-94(61-183)119(206)153-59-105(195)159-93(50-101(148)191)139(226)180-42-26-34-96(180)133(220)163-81(33-23-25-41-143)121(208)177-112(71(13)185)137(224)157-70(12)116(203)165-89(49-100(147)190)130(217)175-110(67(8)9)140(227)181-43-27-35-97(181)134(221)164-83(37-39-99(146)189)123(210)179-114(73(15)187)141(228)229)176-122(209)82(36-38-98(145)188)162-125(212)85(45-65(4)5)167-126(213)87(47-75-54-150-79-31-21-20-30-77(75)79)171-138(225)113(72(14)186)178-131(218)90(51-106(196)197)158-104(194)58-152-118(205)84(44-64(2)3)166-132(219)95(62-184)173-120(207)80(32-22-24-40-142)161-115(202)69(11)156-124(211)86(46-74-28-18-17-19-29-74)168-127(214)88(48-76-55-149-63-155-76)169-128(215)91(52-107(198)199)170-129(216)92(53-108(200)201)172-136(223)109(66(6)7)174-117(204)78(144)60-182;3-2(4,5)1(6)7/h17-21,28-31,54-55,63-73,78,80-97,109-114,150,182-187H,16,22-27,32-53,56-62,142-144H2,1-15H3,(H2,145,188)(H2,146,189)(H2,147,190)(H2,148,191)(H,149,155)(H,151,192)(H,152,205)(H,153,206)(H,154,222)(H,156,211)(H,157,224)(H,158,194)(H,159,195)(H,160,193)(H,161,202)(H,162,212)(H,163,220)(H,164,221)(H,165,203)(H,166,219)(H,167,213)(H,168,214)(H,169,215)(H,170,216)(H,171,225)(H,172,223)(H,173,207)(H,174,204)(H,175,217)(H,176,209)(H,177,208)(H,178,218)(H,179,210)(H,196,197)(H,198,199)(H,200,201)(H,228,229);(H,6,7)/t68-,69-,70-,71+,72+,73+,78+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,109+,110+,111+,112+,113+,114+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80.

Products are for research use only. Not for human use.