γ-Amanitin

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.

Product information

CAS Number: 21150-23-2

Molecular Weight: 902.97

Formula: C39H54N10O13S

Chemical Name: 2-[(1R, 4S, 8R, 10S, 13S, 16S, 34S)-34-[(2S)-butan-2-yl]-8, 22-dihydroxy-13-[(2R, 3S)-3-hydroxybutan-2-yl]-2, 5, 11, 14, 27, 30, 33, 36, 39-nonaoxo-27-thia-3, 6, 12, 15, 25, 29, 32, 35, 38-nonaazapentacyclo[14.12.11.0, .0, .0, ]nonatriaconta-18(26), 19(24), 20, 22-tetraen-4-yl]acetamide

Smiles: CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CC3C4=CC=C(O)C=C4NC=3S(=O)C[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H]([C@@H](C)[C@H](C)O)C(=O)N2

InChiKey: WVHGJJRMKGDTEC-ZUROAWGWSA-N

InChi: InChI=1S/C39H54N10O13S/c1-5-16(2)31-36(59)42-12-29(54)43-26-15-63(62)38-22(21-7-6-19(51)8-23(21)46-38)10-24(33(56)41-13-30(55)47-31)44-37(60)32(17(3)18(4)50)48-35(58)27-9-20(52)14-49(27)39(61)25(11-28(40)53)45-34(26)57/h6-8,16-18,20,24-27,31-32,46,50-52H,5,9-15H2,1-4H3,(H2,40,53)(H,41,56)(H,42,59)(H,43,54)(H,44,60)(H,45,57)(H,47,55)(H,48,58)/t16-,17-,18-,20+,24-,25-,26-,27-,31-,32-,63?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. He K, Mao Q, Zang X, Zhang Y, Li H, Zhang D. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61.

Products are for research use only. Not for human use.