Catalog No. Size PriceQuantity
M12192-2 2mg solid $270
M12192-10 10mg solid $1,040


TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

Product information

CAS Number: 1603845-32-4

Molecular Weight: 580.68

Formula: C32H36N8O3

Chemical Name: N-(5-{1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-amino-1H-pyrazolo[3, 4-d]pyrimidin-3-yl}-2-phenoxyphenyl)prop-2-enamide

Smiles: CC(=O)N1CCN(CC1)C1CCC(CC1)N1N=C(C2=C(N)N=CN=C12)C1=CC(NC(=O)C=C)=C(C=C1)OC1C=CC=CC=1


InChi: InChI=1S/C32H36N8O3/c1-3-28(42)36-26-19-22(9-14-27(26)43-25-7-5-4-6-8-25)30-29-31(33)34-20-35-32(29)40(37-30)24-12-10-23(11-13-24)39-17-15-38(16-18-39)21(2)41/h3-9,14,19-20,23-24H,1,10-13,15-18H2,2H3,(H,36,42)(H2,33,34,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 3.85 mg/mL (6.63 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.


  1. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

Products are for research use only. Not for human use.

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