TX1-85-1

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

Product information

CAS Number: 1603845-32-4

Molecular Weight: 580.68

Formula: C32H36N8O3

Chemical Name: N-(5-{1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-amino-1H-pyrazolo[3, 4-d]pyrimidin-3-yl}-2-phenoxyphenyl)prop-2-enamide

Smiles: CC(=O)N1CCN(CC1)C1CCC(CC1)N1N=C(C2=C(N)N=CN=C12)C1=CC(NC(=O)C=C)=C(C=C1)OC1C=CC=CC=1

InChiKey: FYICDSWKKFSYOM-UHFFFAOYSA-N

InChi: InChI=1S/C32H36N8O3/c1-3-28(42)36-26-19-22(9-14-27(26)43-25-7-5-4-6-8-25)30-29-31(33)34-20-35-32(29)40(37-30)24-12-10-23(11-13-24)39-17-15-38(16-18-39)21(2)41/h3-9,14,19-20,23-24H,1,10-13,15-18H2,2H3,(H,36,42)(H2,33,34,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 3.85 mg/mL (6.63 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.

References:

1. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

Products are for research use only. Not for human use.