L-Glutamic acid


Catalog No. Size PriceQuantity
M12400-2 2mg solid $80
M12400-10 10mg solid $240

Description

L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

Product information

CAS Number: 56-86-0

Molecular Weight: 147.13

Formula: C5H9NO4

Chemical Name: (2S)-2-aminopentanedioic acid

Smiles: N[C@@H](CCC(O)=O)C(O)=O

InChiKey: WHUUTDBJXJRKMK-VKHMYHEASA-N

InChi: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 6.25 mg/mL (42.48 mM; Need ultrasonic) DMSO : 2 mg/mL (13.59 mM; ultrasonic and warming and heat to 60°C)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

L-Glutamic acid could act on [3H]DA release through presynaptic glutamatergic receptors. L-glutamic acid (50 μM) still stimulated the release of [3H] DA in the presence of tetrodotoxin (0.5 μM).

References:

  1. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.

Products are for research use only. Not for human use.

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