L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
CAS Number: 56-86-0
Molecular Weight: 147.13
Chemical Name: (2S)-2-aminopentanedioic acid
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 6.25 mg/mL (42.48 mM; Need ultrasonic) DMSO : 2 mg/mL (13.59 mM; ultrasonic and warming and heat to 60°C)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
L-Glutamic acid could act on [3H]DA release through presynaptic glutamatergic receptors. L-glutamic acid (50 μM) still stimulated the release of [3H] DA in the presence of tetrodotoxin (0.5 μM).
- Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.
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