Malachite green oxalate


Catalog No. Size PriceQuantity
M12566-2 2mg solid $80
M12566-10 10mg solid $240

Description

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo.

Product information

CAS Number: 2437-29-8

Molecular Weight: 927.00

Formula: C52H54N4O12

Chemical Name: [4-[[4-(dimethylamino)phenyl]-phenylmethylidene]cyclohexa-2, 5-dien-1-ylidene]-dimethylazanium;2-hydroxy-2-oxoacetate;oxalic acid

Smiles: C[N+](C)=C1C=CC(C=C1)=C(C1C=CC=CC=1)C1C=CC(=CC=1)N(C)C.C[N+](C)=C1C=CC(C=C1)=C(C1C=CC=CC=1)C1C=CC(=CC=1)N(C)C.[O-]C(=O)C(O)=O.[O-]C(=O)C(O)=O.OC(=O)C(O)=O

InChiKey: CNYGFPPAGUCRIC-UHFFFAOYSA-L

InChi: InChI=1S/2C23H25N2.3C2H2O4/c2*1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4;3*3-1(4)2(5)6/h2*5-17H,1-4H3;3*(H,3,4)(H,5,6)/q2*+1;;;/p-2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (53.94 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13.
  2. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91.
  3. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.

Products are for research use only. Not for human use.

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