Description
Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
Product information
Molecular Weight: 541.98
Formula: C23H32ClN5O8
Chemical Name: N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-2-(2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-ylamino)acetamide hydrochloride
Smiles: Cl.NCCOCCOCCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey: RIVNXFFULWPJRI-UHFFFAOYSA-N
InChi: InChI=1S/C23H31N5O8.ClH/c24-6-8-34-10-12-36-13-11-35-9-7-25-19(30)14-26-16-3-1-2-15-20(16)23(33)28(22(15)32)17-4-5-18(29)27-21(17)31;/h1-3,17,26H,4-14,24H2,(H,25,30)(H,27,29,31);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
- Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Products are for research use only. Not for human use.
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