m-PEG5-Ms


Catalog No. Size PriceQuantity
M13257-2 Contact sales@xcessbio.com for quotation $100
M13257-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG5-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 130955-38-3

Molecular Weight: 330.40

Formula: C12H26O8S

Chemical Name: 2,5,8,11,14-pentaoxahexadecan-16-yl methanesulfonate

Smiles: COCCOCCOCCOCCOCCOS(C)(=O)=O

InChiKey: GIZXGFFADYUCPD-UHFFFAOYSA-N

InChi: InChI=1S/C12H26O8S/c1-15-3-4-16-5-6-17-7-8-18-9-10-19-11-12-20-21(2,13)14/h3-12H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

References:

  1. Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.

Products are for research use only. Not for human use.

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