m-PEG11-Tos


Catalog No. Size PriceQuantity
M13262-2 Contact sales@xcessbio.com for quotation $100
M13262-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

Molecular Weight: 626.75

Formula: C28H50O13S

Chemical Name: 2,5,8,11,14,17,20,23,26,29-decaoxahentriacontan-31-yl 4-methylbenzene-1-sulfonate

Smiles: CC1C=CC(=CC=1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

InChiKey: PMVRKGLJXOGXGW-UHFFFAOYSA-N

InChi: InChI=1S/C28H50O13S/c1-27-3-5-28(6-4-27)42(29,30)41-26-25-40-24-23-39-22-21-38-20-19-37-18-17-36-16-15-35-14-13-34-12-11-33-10-9-32-8-7-31-2/h3-6H,7-26H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Products are for research use only. Not for human use.

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