β-Aminopropionitrile


Catalog No. Size PriceQuantity
M13329-2 2mg solid $80
M13329-10 10mg solid $240

Description

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes.

Product information

CAS Number: 151-18-8

Molecular Weight: 70.09

Formula: C3H6N2

Chemical Name: 3-aminopropanenitrile

Smiles: NCCC#N

InChiKey: AGSPXMVUFBBBMO-UHFFFAOYSA-N

InChi: InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 130 mg/mL (1854.76 mM; Need ultrasonic). H2O : 50 mg/mL (713.37 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro.

References:

  1. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.
  2. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.

Products are for research use only. Not for human use.

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