m-PEG9-phosphonic acid


Catalog No. Size PriceQuantity
M13369-2 Contact sales@xcessbio.com for quotation $100
M13369-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG9-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 2055016-25-4

Molecular Weight: 492.50

Formula: C19H41O12P

Chemical Name: (2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl)phosphonic acid

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCP(O)(O)=O

InChiKey: UEQSLJQFVIWCCW-UHFFFAOYSA-N

InChi: InChI=1S/C19H41O12P/c1-23-2-3-24-4-5-25-6-7-26-8-9-27-10-11-28-12-13-29-14-15-30-16-17-31-18-19-32(20,21)22/h2-19H2,1H3,(H2,20,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Products are for research use only. Not for human use.

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