TCO-PEG8-acid


Catalog No. Size PriceQuantity
M13433-2 Contact sales@xcessbio.com for quotation $100
M13433-10 Contact sales@xcessbio.com for quotation $100

Description

TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 2353410-03-2

Molecular Weight: 593.70

Formula: C28H51NO12

Chemical Name: 1-({[(4Z)-cyclooct-4-en-1-yloxy]carbonyl}amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:37|

InChiKey: LIPCJNZAKQKTRV-UPHRSURJSA-N

InChi: InChI=1S/C28H51NO12/c30-27(31)8-10-33-12-14-35-16-18-37-20-22-39-24-25-40-23-21-38-19-17-36-15-13-34-11-9-29-28(32)41-26-6-4-2-1-3-5-7-26/h1-2,26H,3-25H2,(H,29,32)(H,30,31)/b2-1-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Products are for research use only. Not for human use.

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