Description
m-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 869718-80-9
Molecular Weight: 409.48
Formula: C17H35N3O8
Chemical Name: 25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane
Smiles: COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChiKey: ANQOCZRUHGJYCX-UHFFFAOYSA-N
InChi: InChI=1S/C17H35N3O8/c1-21-4-5-23-8-9-25-12-13-27-16-17-28-15-14-26-11-10-24-7-6-22-3-2-19-20-18/h2-17H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.
Products are for research use only. Not for human use.
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