m-PEG3-Sulfone-PEG3-acid


Catalog No. Size PriceQuantity
M13711-2 Contact sales@xcessbio.com for quotation $100

Description

m-PEG3-Sulfone-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1919045-04-7

Molecular Weight: 416.48

Formula: C16H32O10S

Chemical Name: 3-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethanesulfonyl}ethoxy)ethoxy]ethoxy}propanoic acid

Smiles: COCCOCCOCCS(=O)(=O)CCOCCOCCOCCC(O)=O

InChiKey: CLINTTTZSLFCQX-UHFFFAOYSA-N

InChi: InChI=1S/C16H32O10S/c1-21-4-5-23-8-10-25-12-14-27(19,20)15-13-26-11-9-24-7-6-22-3-2-16(17)18/h2-15H2,1H3,(H,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Products are for research use only. Not for human use.

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