Thalidomide-O-amido-PEG3-C2-NH2


Catalog No. Size PriceQuantity
M13734-2 Contact sales@xcessbio.com for quotation $100

Description

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

Product information

CAS Number: 1957236-20-2

Molecular Weight: 506.51

Formula: C23H30N4O9

Chemical Name: N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

Smiles: NCCOCCOCCOCCNC(=O)COC1C=CC=C2C=1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: QIUJTJGNIBUEJO-UHFFFAOYSA-N

InChi: InChI=1S/C23H30N4O9/c24-6-8-33-10-12-35-13-11-34-9-7-25-19(29)14-36-17-3-1-2-15-20(17)23(32)27(22(15)31)16-4-5-18(28)26-21(16)30/h1-3,16H,4-14,24H2,(H,25,29)(H,26,28,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation.

Products are for research use only. Not for human use.

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