Description
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer.
Product information
Molecular Weight: 395.41
Formula: C21H19F2N5O
Chemical Name: 8-(5-(difluoromethyl)pyridin-3-yl)-1-(oxepan-4-yl)-[1, 2, 4]triazolo[4, 3-a]quinoxaline
Smiles: FC(F)C1C=NC=C(C=1)C1=CC2=C(C=C1)N=CC1=NN=C(C3CCCOCC3)N12
InChiKey: AMSAFRUVFIAWDP-UHFFFAOYSA-N
InChi: InChI=1S/C21H19F2N5O/c22-20(23)16-8-15(10-24-11-16)14-3-4-17-18(9-14)28-19(12-25-17)26-27-21(28)13-2-1-6-29-7-5-13/h3-4,8-13,20H,1-2,5-7H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
BAY-8400 (150 mg/kg; p.o.) increases the antitumor efficacy. BAY-8400 shows useful aqueous solubility and oral bioavailability across species.
Products are for research use only. Not for human use.
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