STING agonist-1

Catalog No. Size PriceQuantity
M21644-C Contact for quotation $100Unavailable


STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.

Product information

CAS Number: 702662-50-8

Molecular Weight: 430.88

Formula: C21H16ClFN2O3S

Chemical Name: (Z)-4-[(2-chloro-6-fluorophenyl)methyl]-N-[(furan-2-yl)methyl]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboximidic acid

Smiles: O/C(=N\CC1=CC=CO1)/C1=CC2=C(C=C1)SCC(=O)N2CC1=C(F)C=CC=C1Cl


InChi: InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (232.08 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 is an indirect activator of human STING-dependent phenotypes. G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling. STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity. G10 induces STING-dependent synthesis and secretion of bioactive interferon. G10 induces innate antiviral mRNA expression in primary human cells.

Products are for research use only. Not for human use.

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