Tipepidine hydrochloride


Catalog No. Size PriceQuantity
M21728-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.

Product information

CAS Number: 1449686-84-3

Molecular Weight: 311.89

Formula: C15H18ClNS2

Chemical Name: 3-[bis(thiophen-2-yl)methylidene]-1-methylpiperidine hydrochloride

Smiles: Cl.CN1CC(CCC1)=C(C1=CC=CS1)C1=CC=CS1

InChiKey: MICLPSFJJVIDJE-UHFFFAOYSA-N

InChi: InChI=1S/C15H17NS2.ClH/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;/h3-4,6-7,9-10H,2,5,8,11H2,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 41.67 mg/mL (133.60 mM; Need ultrasonic). H2O : 3.33 mg/mL (10.68 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats.

Products are for research use only. Not for human use.

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